Glycoxidation and oxidative stress in Parkinson illness and diffuse Lewy physique illness.
- Oxidative stress is properly accepted as an essential pathogenic think about Parkinson illness, based mostly largely on oblique proof. Just lately, now we have developed antiour bodies that acknowledge particular superior glycation end-products (anti–pentosidine and anti–pyrraline), protein modifications which are potentiated by oxidative stress in a course of termed glycoxidation.
- We utilized these antiour bodies immunocytochemically to affected areas in Parkinson illness and diffuse Lewy physique illness brains. Moreover, we used antiour bodies to heme oxygenase-1, a putative marker of oxidative stress response.
Anti-Human Serum IgA (alpha) Antibody (HRP)
- Immunoreactivity to pentosidine, pyrraline, and heme oxygenase-1 was seen within the substantia nigra of Parkinson illness and the neocortex of diffuse Lewy physique illness.
- Heme oxygenase-1 was additional demonstrated by immunoelectron microscopy in intimate affiliation with filaments of cortical Lewy our bodies.
Human Anti-Immunoglobulin A Antibody (Anti-IgA) ELISA Kit
- Immunolocalization of superior glycation end-products and a marker of oxidative stress response induction offers proof that glycoxidation and oxidative stress could also be an essential pathogenic think about ailments characterised by Lewy physique formation, and furthers the proof that cytoskeletal proteins and their inclusions are prone to oxidative stress.
 anti-TNF alpha |
|
YF-PA24865 |
Abfrontier |
50 ul |
EUR 334 |
|
Description: Mouse polyclonal to TNF alpha |
 Anti-human TNF-alpha antibody |
|
STJ15100115 |
St John's Laboratory |
250 µg |
EUR 367 |
|
Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in Flow cytometry and Western blot. |
Anti-human TNF-alpha antibody |
|
STJ15100116 |
St John's Laboratory |
250 µg |
EUR 336 |
|
Description: We recommend MT25C5 as capture antibody in ELISA and ELISpot in combination with biotinylated detection antibody MT20D9. |
Anti-human TNF-alpha antibody |
|
STJ15100117 |
St John's Laboratory |
250 µg |
EUR 367 |
|
Description: This monoclonal antibody enables sensitive and specific detection of human TNF-α in immunoassays such as ELISA and ELISpot. |
 Anti-TNF alpha Purified |
|
11-687-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-TNF alpha Purified |
|
11-687-C100 |
ExBio |
0.1 mg |
EUR 158 |
Anti-TNF alpha Purified |
|
11-688-C025 |
ExBio |
0.025 mg |
EUR 99 |
Anti-TNF alpha Purified |
|
11-688-C100 |
ExBio |
0.1 mg |
EUR 158 |
 Anti-TNF alpha APC |
|
1A-688-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-TNF alpha APC |
|
1A-688-T100 |
ExBio |
100 tests |
EUR 240 |
 Anti-TNF alpha FITC |
|
1F-688-T025 |
ExBio |
25 tests |
EUR 122 |
Anti-TNF alpha FITC |
|
1F-688-T100 |
ExBio |
100 tests |
EUR 204 |
 Anti-TNF alpha PE |
|
1P-688-T025 |
ExBio |
25 tests |
EUR 140 |
Anti-TNF alpha PE |
|
1P-688-T100 |
ExBio |
100 tests |
EUR 240 |
 Anti-TNF alpha Antibody |
|
A00002-2 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-TNF alpha Antibody |
|
A00002-3 |
BosterBio |
100ug/vial |
EUR 294 |
 anti- TNF alpha antibody |
|
FNab08815 |
FN Test |
100µg |
EUR 585 |
- Recommended dilution: WB: 1:500-1:5000
- IHC: 1:200-1:1000
- Immunogen: tumor necrosis factor(TNF superfamily, member 2)
- Uniprot ID: P01375
- Research Area: Signal Transduction, Cardiovascular, Cancer, Immunology, Neuroscience
|
|
Description: Antibody raised against TNF alpha |
 anti- TNF-alpha antibody |
|
FNab08821 |
FN Test |
100µg |
EUR 585 |
- Recommended dilution: WB: 1:200-1:1000
- IHC: 1:50-1:500
- Immunogen: tumor necrosis factor(TNF superfamily, member 2)
- Uniprot ID: P01375
- Research Area: Immunology, Cardiovascular, Developmental biology, Signal Transduction
|
|
Description: Antibody raised against TNF-alpha |
anti- TNF alpha antibody |
|
FNab09822 |
FN Test |
100µg |
EUR 548.75 |
- Recommended dilution: WB: 1:1000 - 1:2000
- IHC: 1:50 - 1:100
- Immunogen: tumor necrosis factor (TNF superfamily, member 2)
- Uniprot ID: P01375
- Gene ID: 7124
- Research Area: Signal Transduction, Cardiovascular, Cancer, Immunology, Neuroscience
|
|
Description: Antibody raised against TNF alpha |
Anti-TNF alpha Antibody |
|
PA1079 |
BosterBio |
100ug/vial |
EUR 334 |
) anti-TNF-alpha (2A9B9) |
|
LF-MA30138 |
Abfrontier |
100 ul |
EUR 486 |
|
Description: Mouse Monoclonal to TNF-alpha |
Anti-TNF alpha Antibody |
|
PB9010 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-TNF alpha Antibody |
|
PB9246 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-TNF alpha antibody |
|
STJ140123 |
St John's Laboratory |
150 µg |
EUR 408 |
|
Description: Goat polyclonal antibody to TNF alpha. TNF-alpha is produced by a variety of immune cells including NK cells, B cells, T cells and macrophages. It is multifunctional proinflammatory cytokine that belongs to the tumour necrosis factor (TNF) superfamily. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is involved in the regulation of several processes including lipid metabolism cell differentiation and proliferation, coagulation and apoptosis. It has been implicated in a variety of diseases, including cancer and autoimmune diseases. |
 Anti-TNF-alpha antibody |
|
STJ96054 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: TNF-alpha is a protein encoded by the TNF gene which is approximately 25,6 kDa. TNF-alpha is localised to the cell membrane. It is involved in PEDF induced signalling, TNFR1 pathway, allograft rejection and apoptosis modulation and signalling. It is a cytokine that is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, lipid metabolism, and coagulation. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-alpha is expressed in the blood, lung, spleen, liver and heart. Mutations in the TNF gene may result in psoriatic arthritis. STJ96054 was affinity purified. This polyclonal antibody binds to endogenous TNF-alpha. |
Anti-TNF-alpha antibody |
|
STJ96516 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to TNF-alpha. |
Anti-TNF alpha antibody |
|
STJ97488 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to TNF alpha. |
Anti-TNF alpha antibody |
|
STJ97489 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to TNF alpha. |
Anti-TNF alpha antibody |
|
STJ97493 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Mouse monoclonal to TNF alpha. |
Anti-TNF alpha antibody |
|
STJ97494 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Mouse monoclonal to TNF alpha. |
 IgG #1 aff. Pure) Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #1 aff. Pure |
|
TNFA11-M |
Alpha Diagnostics |
100 ug |
EUR 482 |
 IgG #2, aff. Pure) Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure |
|
TNFA12-M |
Alpha Diagnostics |
100 ug |
EUR 482 |
 antiserum) Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE) antiserum |
|
TACE11-S |
Alpha Diagnostics |
100 ul |
EUR 457 |
 IgG #2, aff. Pure (neutralzing)) Goat Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure (neutralzing) |
|
TNFA13-A |
Alpha Diagnostics |
100 ul |
EUR 482 |
 Anti-human/monkey TNF-alpha antibody |
|
STJ15100118 |
St John's Laboratory |
250 µg |
EUR 336 |
|
Description: This monoclonal antibody enables sensitive and specific detection of monkey TNF-α in immunoassays such as ELISA and ELISpot. |
Anti-human/monkey TNF-alpha antibody |
|
STJ15100119 |
St John's Laboratory |
250 µg |
EUR 367 |
|
Description: This monoclonal antibody enables sensitive and specific detection of TNF-α in immunoassays such as ELISA and ELISpot, Flow cytometry, and Western blot. |
 Anti-mouse TNF alpha Antibody |
|
RP1000 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-mouse TNF-alpha antibody |
|
STJ15100113 |
St John's Laboratory |
250 µg |
EUR 336 |
|
Description: These monoclonal antibodies enable sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot. |
Anti-mouse TNF-alpha antibody |
|
STJ15100114 |
St John's Laboratory |
250 µg |
EUR 367 |
|
Description: This monoclonal antibody enables sensitive and specific detection of mouse TNF-α in immunoassays such as ELISA and ELISpot. |
) Anti-TNF alpha (M1-C4) |
|
YF-MA10949 |
Abfrontier |
100 ug |
EUR 363 |
|
Description: Mouse monoclonal to TNF alpha |
) Anti-TNF alpha (M2-E3) |
|
YF-MA15915 |
Abfrontier |
100 ug |
EUR 363 |
|
Description: Mouse monoclonal to TNF alpha |
 Human TNF-alpha ELISA Kit, 96 tests, Quantitative |
|
100-215-TNH |
Alpha Diagnostics |
1 kit |
EUR 482 |
, IgG aff. Pure) Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE), IgG aff. Pure |
|
TACE11-A |
Alpha Diagnostics |
100 ug |
EUR 482 |
, Human IgG4 Antibody) Anti-TNF alpha (Humicade), Human IgG4 Antibody |
|
A1093-200 |
Biovision |
|
EUR 729 |
, Human IgG1 Antibody) Anti-TNF alpha (Infliximab), Human IgG1 Antibody |
|
A1097-200 |
Biovision |
|
EUR 778 |
 Human anti TNF Alpha autoantibody ELISA kit |
|
E01A2132-192T |
B-Gene |
192 tests |
EUR 1270 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
|
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human anti TNF Alpha autoantibody ELISA kit |
|
E01A2132-48 |
B-Gene |
1 plate of 48 wells |
EUR 520 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
|
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human anti TNF Alpha autoantibody ELISA kit |
|
E01A2132-96 |
B-Gene |
1 plate of 96 wells |
EUR 685 |
- Kit contents: 1. MICROTITER PLATE * 1
2. ENZYME CONJUGATE*1 vial
3. STANDARD A*1 vial
4. STANDARD B*1 vial
5. STANDARD C*1 vial
6. STANDARD D*1 vial
7. STANDARD E*1 vial
8. STANDARD F*1 vial
9. SUBSTRATE A*1 vial
10. SUBSTRATE B*1 vial
11. STOP SOLUT
- Show more
|
|
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active) Recombinant (E.Coli) purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active |
|
TNFA15-R-10 |
Alpha Diagnostics |
10 ug |
EUR 225 |
 Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-20ug |
|
7124-RBM13-P0 |
EnQuireBio |
20ug |
EUR 233 |
 Anti-TNF-alpha Antibody Clone TNF/1500R, Unconjugated-100ug |
|
7124-RBM13-P1 |
EnQuireBio |
100ug |
EUR 428 |
 Rabbit Polyclonal antibody Anti-CRBN |
|
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
 Rapid Test cards, 10/pk) TruStrip RDT Humira/Adalimumab (anti-TNF-alpha) Rapid Test cards, 10/pk |
|
200-320-RDT |
Alpha Diagnostics |
1 pk |
EUR 293 |
 Human TNF-alpha antibody |
|
32809-05111 |
AssayPro |
150 ug |
EUR 261 |
 TNF-alpha, human recombinant |
|
1050-10 |
Biovision |
|
EUR 153 |
TNF-alpha, human recombinant |
|
1050-1000 |
Biovision |
|
EUR 1751 |
TNF-alpha, human recombinant |
|
1050-50 |
Biovision |
|
EUR 283 |
 Human TNF-alpha Antibody |
|
13101-05011 |
AssayPro |
150 ug |
EUR 217 |
 Human TNF alpha Protein |
|
abx060828-005mg |
Abbexa |
0.05 mg |
EUR 551 |
- Shipped within 5-10 working days.
|
 Anti-TNF alpha Purified Azide Free |
|
10-687-C100 |
ExBio |
0.1 mg |
EUR 158 |
) Anti-TNF alpha (1C3-A1-F4) |
|
YF-MA15914 |
Abfrontier |
100 ug |
EUR 363 |
|
Description: Mouse monoclonal to TNF alpha |
 TNF-alpha Antibody |
|
3052R-100 |
Biovision |
|
EUR 316 |
TNF-alpha Antibody |
|
3052R-30T |
Biovision |
|
EUR 146 |
TNF-alpha Antibody |
|
3053R-100 |
Biovision |
|
EUR 316 |
TNF-alpha Antibody |
|
3053R-30T |
Biovision |
|
EUR 146 |
TNF-alpha Antibody |
|
3054-100 |
Biovision |
|
EUR 316 |
TNF-alpha Antibody |
|
3054-30T |
Biovision |
|
EUR 146 |
Particular dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by assuaging irritation and endothelial dysfunction.
OBJECTIVE
Animal and medical studies have prompt that polyphenols in fruits, purple wine, and tea might delay the event of atherosclerosis through their antioxidant and anti-inflammatory properties.
Human Anti-Parainfluenza Virus IgM Antibody (anti-PIV IgM) ELISA Kit
We investigated whether particular person dietary polyphenols representing completely different polyphenolic courses, specifically quercetin (flavonol), (-)-epicatechin (flavan-3-ol), theaflavin (dimeric catechin), sesamin (lignan), or chlorogenic acid (phenolic acid), scale back atherosclerotic lesion formation within the apolipoprotein E (ApoE)(-/-) gene-knockout mouse.
RESULTS
Quercetin and theaflavin (64-mg/kg physique mass every day) considerably attenuated atherosclerotic lesion dimension within the aortic sinus and thoracic aorta (P<0.05 versus ApoE(-/-) management mice). Quercetin considerably decreased aortic F(2)-isoprostane, vascular superoxide, vascular leukotriene B(4), and plasma-sP-selectin concentrations; and augmented vascular endothelial NO synthase exercise, heme oxygenase-1 protein, and urinary nitrate excretion (P<0.05 versus management ApoE(-/-) mice).
Theaflavin confirmed related, though much less intensive, vital results. Though (-)-epicatechin considerably decreased F(2)-isoprostane, superoxide, and endothelin-1 manufacturing (P<0.05 versus management ApoE(-/-) mice), it had no vital impact on lesion dimension. Sesamin and chlorogenic acid therapies exerted no vital results. Quercetin, however not (-)-epicatechin, considerably elevated the expression of heme oxygenase-1 protein in lesions versus ApoE(-/-) controls.
CONCLUSIONS
Particular dietary polyphenols, specifically quercetin and theaflavin, might attenuate atherosclerosis in ApoE(-/-) gene-knockout mice by assuaging inflammation, enhancing NO bioavailability, and inducing heme oxygenase-1.
These information recommend that the cardiovascular safety related to diets wealthy in fruits, greens, and a few drinks might partially be the results of flavonoids, such as quercetin.
Product not found
