RANK Rabbit Polyclonal Antibody

RANK Rabbit Polyclonal Antibody

To Order: garrett@bioworldantibodies.com

RANK antibody
70R-13924 100 ug
EUR 386.4
Description: Affinity purified Rat polyclonal RANK antibody

RANK antibody
10R-6612 100 ug
EUR 424.8
Description: Rat monoclonal RANK antibody

RANK Antibody
R30453 100 ug
EUR 419

RANK Antibody
R31815 100 ug
EUR 419

RANK Antibody
R32806 100ug
EUR 419

RANK Antibody
RQ4403 100 ug
EUR 419

Human Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
DLR-RANk-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Receptor Activator Of Nuclear Factor Kappa B (RANk) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
DLR-RANk-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Receptor Activator Of Nuclear Factor Kappa B (RANk) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
DLR-RANk-Ra-48T 48T
EUR 658.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
DLR-RANk-Ra-96T 96T
EUR 861.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
RD-RANk-Hu-48Tests 48 Tests
EUR 625.2

Human Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
RD-RANk-Hu-96Tests 96 Tests
EUR 867.6

Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
RD-RANk-Ra-48Tests 48 Tests
EUR 668.4

Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
RD-RANk-Ra-96Tests 96 Tests
EUR 930

Human Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
RDR-RANk-Hu-48Tests 48 Tests
EUR 652.8

Human Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
RDR-RANk-Hu-96Tests 96 Tests
EUR 907.2

Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
RDR-RANk-Ra-48Tests 48 Tests
EUR 699.6

Rat Receptor Activator Of Nuclear Factor Kappa B (RANk) ELISA Kit
RDR-RANk-Ra-96Tests 96 Tests
EUR 973.2

RANK
70R-15110 100 ug
EUR 392.4
Description: Rabbit polyclonal RANK

RANK Receptor antibody
70R-RR012 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal RANK Receptor antibody

RANK antibody (HRP)
60R-1176 100 ug
EUR 392.4
Description: Rabbit polyclonal RANK antibody (HRP)

RANK antibody (FITC)
60R-1177 100 ug
EUR 392.4
Description: Rabbit polyclonal RANK antibody (FITC)

RANK antibody (biotin)
60R-1178 100 ug
EUR 392.4
Description: Rabbit polyclonal RANK antibody (biotin)

RANK antibody (PE)
61R-1403 100 ug
EUR 483.6
Description: Rat monoclonal RANK antibody (PE)

RANK antibody (biotin)
61R-1652 100 ug
EUR 444
Description: Rat monoclonal RANK antibody (biotin)

Anti-RANK antibody
STJ98715 200 µl
EUR 236.4
Description: Rabbit polyclonal to RANK.

RANK/ Rat RANK ELISA Kit
ELA-E2057r 96 Tests
EUR 1063.2

Polyclonal TNFRSF11A / RANK Antibody (aa603-613)
APR13769G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF11A / RANK (aa603-613). This antibody is tested and proven to work in the following applications:

RANK protein
30R-2558 10 ug
EUR 403.2
Description: Purified recombinant Human RANK protein

RANK protein
30R-2639 10 ug
EUR 362.4
Description: Purified recombinant Mouse RANK protein

RANK protein
30R-AR024 10 ug
EUR 327.6
Description: Purified recombinant Human RANK protein

RANK protein
30R-AS060 10 ug
EUR 327.6
Description: Purified recombinant Human RANK protein

anti-RANK
YF-PA25184 50 ul
EUR 400.8
Description: Mouse polyclonal to RANK

Anti-RANK-L Antibody
A00363 100ug
EUR 518.4
Description: Rabbit Polyclonal RANK-L Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-RANK/TNFRSF11A Antibody
A01064-1 100ug/vial
EUR 400.8

Anti-RANK/TNFRSF11A Antibody
A01064-2 100ug/vial
EUR 352.8

Anti-RANK/Tnfrsf11a Antibody
A01064-3 100ug/vial
EUR 352.8

Anti-RANK/TNFRSF11A Antibody
PA1382 100ug/vial
EUR 400.8

Anti-RANK/TNFRSF11A Antibody
PB9413 100ug/vial
EUR 352.8

rHu RANK-Ligand
AK8283-0002 2µg Ask for price

rHu RANK-Ligand
AK8283-0010 10µg Ask for price

rHu RANK-Ligand
AK8283-0100 100µg Ask for price

rHu RANK-Ligand
AK8283-1000 1mg Ask for price

RANK Recombinant Protein
92-559 0.05 mg
EUR 500.1
Description: Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.

RANK Receptor protein
30R-AR001 100 ug
EUR 327.6
Description: Purified recombinant Human RANK Receptor protein

RANK Recombinant Protein
90-230 50 ug
EUR 500.1
Description: RANK (TRANCE-R; CD265) is the receptor for RANKL/TRANCE/OPGL. It is essential for RANKL-mediated osteoclastogenesis and is involved in the regulation of interactions between T cells and dendritic cells.

RANK Recombinant Protein
90-276 50 ug
EUR 632.4
Description: RANK (TRANCE-R; CD265) is the receptor for RANKL/TRANCE/OPGL. It is essential for RANKL-mediated osteoclastogenesis and is involved in the regulation of interactions between T cells and dendritic cells.

Anti-RANK Monoclonal Antibody (9A725)
M01064 100ug
EUR 518.4
Description: Mouse Monoclonal RANK Antibody (9A725). Validated in WB and tested in Human, Mouse.

Human RANK ELISA Kit
55R-1765 1 kit
EUR 708
Description: ELISA kit for detection of RANK in the research laboratory

Mouse RANK ELISA Kit
55R-1766 1 kit
EUR 781.2
Description: ELISA kit for detection of RANK in the research laboratory

RANK L Recombinant Protein
92-558 0.05 mg
EUR 821.4
Description: CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.

RANK / TNFRSF11A Recombinant Protein
11-479 0.1 mg
EUR 714.3
Description: RANK / TNFRSF11A is a member of the tumor necrosis factor receptor family. RANK / TNFRSF11A shares significant amino acid homology with other members of the TNF R family in its extracellular four cysteine-rich repeats. Functional genomics in mice showed that RANKL (TNFSF11), a member of the TNF ligand superfamily, and RANK (TNFRSF11a), the cognate TNFR family receptor for RANKL, were essential for osteoclastogenesis in vivo. A functional interaction between RANKL, expressed by bone stromal cells of the osteoblast lineage, and RANK, expressed by osteoclast precursors of hematopoietic myeloid lineage, is necessary for osteoclast differentiation, survival, and activation.

Soluble RANK Ligand Protein
20-abx260745
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Soluble RANK Ligand Protein
20-abx262238
  • EUR 393.60
  • EUR 6991.20
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Soluble RANK Receptor Protein
20-abx263125
  • EUR 393.60
  • EUR 1612.80
  • EUR 276.00
  • 100 ug
  • 1 mg
  • 20 ug

Soluble RANK Ligand Protein
20-abx263182
  • EUR 1779.60
  • EUR 393.60
  • EUR 276.00
  • 0.1 mg
  • 10 ug
  • 2 µg

Mouse Rank ELISA kit
LF-EK50733 1×96T
EUR 777.6

TRANCE/RANK L/TNFSF11
E21-R06 10ug
EUR 411.6

RANK L/TNFSF11, Human
HY-P7424 50ug
EUR 1410

RANK L/TNFSF11, Mouse
HY-P7425 10ug
EUR 501.6

RANK Human Recombinant Protein
PROTQ9Y6Q6-1 Regular: 10ug
EUR 380.4
Description: RANK produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 427 amino acids (28-212a.a.) and having a molecular mass of 47.6kDa. 

Rabbit receptor activator of nuclear factor-kB (RANK) ELISA kit
E04R0392-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit receptor activator of nuclear factor-kB (RANK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit receptor activator of nuclear factor-kB (RANK) ELISA kit
E04R0392-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit receptor activator of nuclear factor-kB (RANK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit receptor activator of nuclear factor-kB (RANK) ELISA kit
E04R0392-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit receptor activator of nuclear factor-kB (RANK) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Receptor Activator Of Nuclear Factor Kappa B (RANk) Polyclonal Antibody (Mouse)
4-PAC057Mu01
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Receptor Activator Of Nuclear Factor Kappa B (RANk)

Recombinant Human Soluble RANK Ligand
CG146-002 2ug
EUR 351.6

Recombinant Human Soluble RANK Ligand
CG146-010 10ug
EUR 489.6

Recombinant Human Soluble RANK Ligand
CG146-101 1mg
EUR 12372

Human RANK PicoKine ELISA Kit
EK0829 96 wells
EUR 523.2
Description: For quantitative detection of human RANK in cell culture supernates and serum.

Mouse RANK PicoKine ELISA Kit
EK0830 96 wells
EUR 571.2
Description: For quantitative detection of mouse RANK in cell culture supernates and serum.

Rat RANK PicoKine ELISA Kit
EK1281 96 wells
EUR 510
Description: For quantitative detection of rat RANK in cell culture supernates and serum.

ELISA kit for Human RANK
EK5369 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human RANK in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse RANK
EK5370 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse RANK in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat RANK
EK5570 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat RANK in samples from serum, plasma, tissue homogenates and other biological fluids.

Soluble RANK Ligand Recombinant Protein
40-296-0002mg 0.002 mg
EUR 311.1
Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant human sRANKL is a 20.0 kDa polypeptide comprising the TNF homologous region of RANKL (176 amino acid residues).

Soluble RANK Ligand Recombinant Protein
40-296-001mg 0.01 mg
EUR 437.1
Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant human sRANKL is a 20.0 kDa polypeptide comprising the TNF homologous region of RANKL (176 amino acid residues).

Soluble RANK Receptor Recombinant Protein
40-300-002mg 0.02 mg
EUR 311.1
Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).

Soluble RANK Receptor Recombinant Protein
40-300-01mg 0.1 mg
EUR 437.1
Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).

Soluble RANK Ligand Recombinant Protein
40-451-0002mg 0.002 mg
EUR 311.1
Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant murine sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).

Soluble RANK Ligand Recombinant Protein
40-451-001mg 0.01 mg
EUR 437.1
Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant murine sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).

Soluble RANK Ligand Recombinant Protein
40-481-0002mg 0.002 mg
EUR 311.1
Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant rat sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).

Soluble RANK Ligand Recombinant Protein
40-481-001mg 0.01 mg
EUR 437.1
Description: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant rat sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues).

Recombinant Human Soluble RANK Ligand
7-01492 2µg Ask for price

Recombinant Human Soluble RANK Ligand
7-01493 10µg Ask for price

Recombinant Human Soluble RANK Ligand
7-01494 1mg Ask for price

Recombinant Mouse Soluble RANK Ligand
7-01501 2µg Ask for price

Recombinant Mouse Soluble RANK Ligand
7-01502 10µg Ask for price

Recombinant Mouse Soluble RANK Ligand
7-01503 1mg Ask for price

RANK ELISA Kit (Human) (OKBB00336)
OKBB00336 96 Tests
EUR 621.6
Description: Description of target: Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain (residues 234-616), which contain three putative TRAF-binding domains (termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK. The standard in this kit is recombinant human RANK with the sequence of Q29-G213 aa. It is a dipolymer which compose of two chains, and the molecular weight of each is 48kda.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 2 pg/ml

RANK ELISA Kit (Mouse) (OKBB00337)
OKBB00337 96 Tests
EUR 684
Description: Description of target: Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain (residues 234-616), which contain three putative TRAF-binding domains (termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 2 pg/ml

RANK ELISA Kit (Rat) (OKBB00578)
OKBB00578 96 Wells
EUR 606
Description: Description of target: Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain (residues 234-616), which contain three putative TRAF-binding domains (termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK. The standard in this kit is recombinant human RANK with the sequence of Q29-G213 aa. It is a dipolymer which compose of two chains, and the molecular weight of each is 48kda.;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

RANK Rabbit Polyclonal Antibody

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